Patients with multiple cancers of head and neck

A total of 20,855 head and neck cancers (HNC), based in the Czech Cancer Registry in 1976–2005, there were notificated 4,912 multiple

cancers, of which were 3,679 (74.9 %) in males and 1,233 (25.1 %) in females, i.e. 17.6 % cases in males and 19.5 % in females of total HNC,

affected by other neoplasms. There were 56.3 % primary and 43.7 % subsequent HNC in males, 43.8 % and 56.2 % in females. The number

of primary HNC incerased during the first decade and then decreased, the number of subsequent HNC increased steadily. A total of 14

Czech regions were distributed 51.6 % multiple HNC in five regions (Northern and Southern Moravia, Prague, Southern and Central Bohemia).

The most frequent were 28.8 % multiple cancers of lips, 11.9 % of tonsils, 11.1 % of parotid gands. The primary 2,070 HNC in males

were followed by 2,436 other neoplasms in the average interval 6.7 years; the primary 540 HNC in females were followed by 649 other

neoplasms in males in the average interval 6.9 years. The most frequent diagnoses of 425 synchronous cases were cancers of respiratory

tract, skin and other HNC, of 2,660 metachronous cases were cancers of skin, respiratory and digestive tract. The subsequent 2.302

HNC were preceded by 2.858 other neoplasms with the most frequent cancers of skin, respiratory tract and other HNC. The expected

low representation of advanced clinical stages was not confirmed. Of 2,436 subsequent neoplasms in males and 649 in females were

registered after early HNC stages in 16.1 % males and 18.6 % females of stages I, II, in 10.7 % males and 7.8 % females of stages III, IV; after

advanced HNC stages were in 8.2 % males and 6.5% females of stages I, II, in 8.9 % males and 5.2 % females of stages III, IV; the unknown

stages represented 56.1 % in males and 61.9 % in females of subsequent neoplasms. All 729 subsequent advanced cancers (606 males,

123 females) represented 3.5 % of total registered cases of HNC during 30 years and about 1,540 patients with HNC affected by other

subsequent cancer of 43,850 HNC based in the Czech Cancer Registry during half-century. Up to Oct. 2007, of the primary HNC 14.7 %

males and 20.6 % females survived, and those 85.3 % males and 79.4 % females died. Nearly 8,000 patients is estimated to be treated for

HNC, some of them with multiple cancers, in the Czech Republic in 2015. Will be reached their expected numbers?

clinical stages.

Keywords: head and neck cancers, multiple occurrence, distribution by age, time, space, synchronous and metachronous cancers,