Onkologie. 2017:11(6):294-298 | DOI: 10.36290/xon.2017.054

Osteosarcoma

Tomáš Tomáš, Pavel Janíček, Lukáš Pazourek, Michal Mahdal

I. ortopedická klinika FN u sv. Anny v Brně, LF MU Brno

Osteosarcoma is the most common primary malignant bone tumour. This tumour occurs mostly in adolescence and in youngadults. With nowaday therapy standards, the long term survival rate is about 70 % in patients with localized extremity diseaseand about 20–30 % in patients with primary metastatic disease or with axial disease. Diagnostics is settled on imaging methods(X-ray, CT, MRI, PET-CT), clinical findings and biopsy. The main point in local treatment is radical resection of the tumour. Modularendoprosthesis are today used for replacement of resected bone, individual endoprosthesis or allografts are used less. Fourstandard chemotherapeutics are fundamentally long term systemic therapy of osteosarcomas: high-dosed methotrexate, doxorubicin,cisplatin and ifosfamide. Using other additional drugs doesn’t improve the results of systemic therapy up to this day. Thefollow up is based on clinical investigation, X- ray and chest CT. The frequency of follow up intervals and validity of chest X-ray incomparsion to CT is a matter of discussion.

Keywords: osteosarcoma, systemic treatment, radiotherapy, surgical therapy

Published: December 1, 2017  Show citation