Onkologie. 2023:17(1):57-61 | DOI: 10.36290/xon.2023.013

Case reports of patients with ALK-positive NSCLC and brain metastases

Petra Zemanová1, 2, Milada Zemanová1, Vladimír Černý3
1 Onkologická klinika, VFN a 1. LF UK v Praze
2 1. klinika tuberkulózy a respiračních nemocí, VFN a 1. LF UK v Praze
3 Radiodiagnostická klinika, VFN a 1. LF UK v Praze

The present case reports describe a young male and a young female patient diagnosed with generalized non-small cell lung adeno­carcinoma with brain metastases and ALK translocation. Brain metastases are detected in 30% of patients with ALK-positive NSCLC at the time of cancer diagnosis. The discussion section deals with the intracranial efficacy of individual ALK inhibitors.

Keywords: non-small cell lung carcinoma, ALK inhibitors, brain metastases.

Accepted: February 22, 2023; Published: March 1, 2023  Show citation

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Zemanová P, Zemanová M, Černý V. Case reports of patients with ALK-positive NSCLC and brain metastases. Onkologie. 2023;17(1):57-61. doi: 10.36290/xon.2023.013.
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