Onkologie. 2023:17(3):205-208 | DOI: 10.36290/xon.2023.041
Patient with upgrading ganglioglioma
- 1 Neurochirurgická klinika, LF UP a FN Olomouc
- 2 Ústav molekulární a klinické patologie, LF UP a FN Olomouc
- 3 Onkologická klinika, LF UP a FN Olomouc
- 4 Ústav molekulární a translační medicíny, LF UP v Olomouci
Ganglioglioma is a rare primary brain tumor. It is commonly located supratentorialy, in the temporal lobe (>70%). The main clinical manifestation is a drug-resistant epileptic seizures. A rare, anaplastic, form is considered based on histological anaplastic signs of the glial component. Our patient with WHO grade 1 ganglioglioma underwent several surgeries for the gradual neoplasm progression. The histological examination shows the tumor development and its gradual up-grading into an anaplastic form (WHO grade 3), of which biology corresponded with the IDH wild-type glioblastoma. Current molecular-genetic tumor profiling is underpinnings for predilection of the biologic and clinic behavior and also for the assessment of follow-up and treatment strategy.
Keywords: ganglioglioma, anaplastic ganglioglioma, tumor upgrading, glioblastoma, IDH wild-type.
Accepted: June 12, 2023; Published: June 16, 2023 Show citation
References
- Louis DN, Perry A, Wesseling P, et al. The 2021 WHO Classification of Tumors of the Central Nervous System: a summary. Neuro-Oncology [Internet]. 2021;23(8):1231-1251. Available from: doi:10.1093/neuonc/noab106.
Go to original source... 
Go to PubMed... - Greenberg M. Ependymal, Choroid Plexus, & Neuronal Tumors and Other Gliomas In: Greenberg M, Handbook of Neurosurgery ed. New York: Thieme; 2019:662-663.
- Rogojan L, Olinici CD. Ganglioglioma with glioblastoma component. Rom J Morphol Embryol. 2008;49(3):403-406. PMID: 18758648.
- Pujadas E, Chen L, Rodriguez FJ. Pathologic and molecular aspects of anaplasia in circumscribed gliomas and glioneuronal tumors. Brain Tumor Pathology [Internet]. 2019;36(2):40-51. Available from: doi:10.1007/s10014-019-00336-z. Go to original source... Go to PubMed...
- Luyken C, Blümcke I, Fimmers R, et al. Supratentorial gangliogliomas: histopathologic grading and tumor recurrence in 184 patients with a median follow-up of 8 years. Cancer. 2004;101(1):146-155. doi: 10.1002/cncr.20332. PMID: 15222000. Go to original source... Go to PubMed...
- Lang FF, Epstein FJ, Ransohoff J, et al. Central Nervous System Gangliogliomas. Part 2: Clinical Outcome. J Neurosurg. 1993;79:867-873. Go to original source... Go to PubMed...
- Reinhardt A, Pfister K, Schrimpf D, et al. Anaplastic ganglioglioma - A diagnosis comprising several distinct tumour types. Neuropathology and Applied Neurobiology [Internet]. 2022;48(7). Available from: doi:10.1111/nan.12847. Go to original source... Go to PubMed...
- Pekmezci M, Javier E, Meyer V, et al. The genetic landscape of ganglioglioma. Acta Neuropathologica Communications [Internet]. 2018;6(1). Available from: doi:10.1186/s40478-018-0551-z. Go to original source... Go to PubMed...
- Naydenov E, Tzekov C, Minkin K, et al. Malignant progression of an anaplastic ganglioglioma into a glioblastoma multiforme-report on two cases and review of the literature. Khirurgiia (Sofiia). 2009;(2-3):69-74. Bulgarian. PMID: 20506796.
- Hayashi Y, Iwato M, Hasegawa M, et al. Malignant transformation of a gangliocytoma/ganglioglioma into a glioblastoma multiforme: a molecular genetic analysis. Case report. J Neurosurg. 2001;95(1):138-142. doi: 10.3171/jns.2001.95.1.0138. PMID: 11453385. Go to original source... Go to PubMed...