Onkologie. 2009:3(1):62-65

Prevention of jaw osteonecrosis prior to oncological therapy

Radomír Hodan1, Maryla Mendreková2, Josef Gruna2, Jakub Cvek3
1 Klinika ústní, čelistní a obličejové chirurgie, FN Ostrava
2 Onkologické centrum J. G. Mendela, Nový Jičín
3 Klinika radiační onkologie FN Ostrava

Osteonecrosis of the jaw is an uncommon but feared complication of long-term therapy with bisphosphonates in patients with tumoral

metastases to the skeleton.

Osteoradionecrosis of the lower jaw arises as a serious late complication related to radiotherapy in the oral cavity. These complications

significantly interfere with the quality of life and food intake. The mechanism of origin of osteonecrosis is not well understood but

adherence to preventive measures prior to and during the therapy with bisphosphonates or radiotherapy in the oral cavity would most

likely result in a reduced incidence of this unpleasant complication.

Keywords: osteonecrosis, osteoradionecrosis, bisphosphonates.

Published: March 1, 2009  Show citation

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Hodan R, Mendreková M, Gruna J, Cvek J. Prevention of jaw osteonecrosis prior to oncological therapy. Onkologie. 2009;3(1):62-65.
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