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doc. MUDr. Renata Soumarová, Ph.D., MBA

Onkologie 2020: 14(Suppl.A)  

Incidental finding of pancreatic duct dilation as the sign of asymptomatic pancreatic cancer

Pavel Záruba, Miroslav Ryska

Onkologie 2020: 14(Suppl.A): 5-8 | DOI: 10.36290/xon.2020.027  

Pancreatic carcinoma has a poor prognosis. Typically, it hasn´t any specific symptoms in the early stages. Incidentally found dilation of pancreatic duct could be this sign. When it´s present there active approach and correct evaluation of all results are needed. The case study presents patient in oncological follow-up diagnosed for pancreatic duct dilation without any clinical signs. The initial imaging examination didn´t explain any cause of dilation. After that, the patient was diagnosed and operated for the malignant lesion of the pancreatic head.

Pembrolizumab in treating an 82-year-old female patient with NSCLC

Juraj Kultan

Onkologie 2020: 14(Suppl.A): 9-12 | DOI: 10.36290/xon.2020.028  

Elderly patients account for a substantial proportion of newly diagnosed lung cancer cases. Advanced chronological age is not considered a contraindication to active treatment; however, specific issues of this population have to be taken into account. We report a case of a patient who, despite her older age, has benefited from further evaluation and treatment of metastatic lung cancer with immunotherapy.

A giant exulcerated adenomyoepithelioma of the breast

Lucia Veverková, Ivan Šišola, Ľubica Löwová, Jana Janková, Markéta Kolečková, Nora Zlámalová, Katherine Vomáčková

Onkologie 2020: 14(Suppl.A): 13-16 | DOI: 10.36290/xon.2020.029  

Malignant tumors of the mammary gland - most commonly invasive ductal carcinoma (according to the new histological classification invasive carcinoma NST - no special type) and invasive lobular cancer are most frequently seen in the locally advanced breast tumors with ulceration of the skin. This report describes a histologically rare case of locally advanced malignant breast adenomyoepithelioma. A patient with locally advanced exulcerated breast tumor, with benign preoperative histopathological finding of benign adenomyoepithelioma, underwent a radical mastectomy at our department. The definitive histology suggests that it was a benign adenomyoepithelioma...

Serious complications in a patient with generalized non-small cell lung cancer treated with pembrolizumab

Jan Stejskal

Onkologie 2020: 14(Suppl.A): 17-20 | DOI: 10.36290/xon.2020.030  

Treatment with pembrolizumab was initiated in a patient with generalized NSCLC with a PD-L1 expression of 90 %. After four months of treatment, he suddenly developed toxicity (irAEs) - exacerbation of grade 3 ulcerative colitis and other serious complications which required cardiopulmonary resuscitation. The life-threatening condition was managed successfully and the patient continues to receive immunotherapy.